InnateDB Protein
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IDBP-378611.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PSMA4
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Protein Name
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proteasome (prosome, macropain) subunit, alpha type, 4
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Synonyms
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HC9; HsT17706; PSC9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402118
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InnateDB Gene
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IDBG-24777 (PSMA4)
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Protein Structure
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Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
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Subcellular Localization |
Cytoplasm. Nucleus. Cytoplasm, P-body {ECO:0000250}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
116
[view]
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Protein-Protein |
112
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
4
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
GO:0000082
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G1/S transition of mitotic cell cycle
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GO:0000209
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protein polyubiquitination
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GO:0000278
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mitotic cell cycle
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GO:0002474
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antigen processing and presentation of peptide antigen via MHC class I
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GO:0002479
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antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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GO:0006521
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regulation of cellular amino acid metabolic process
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GO:0006915
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apoptotic process
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GO:0006977
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DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
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GO:0010467
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gene expression
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GO:0016032
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viral process
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GO:0016070
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RNA metabolic process
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GO:0016071
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mRNA metabolic process
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0034641
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cellular nitrogen compound metabolic process
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GO:0042590
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antigen processing and presentation of exogenous peptide antigen via MHC class I
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GO:0042981
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regulation of apoptotic process
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GO:0043066
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negative regulation of apoptotic process
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GO:0044281
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small molecule metabolic process
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051603
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proteolysis involved in cellular protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR001353
Proteasome, subunit alpha/beta
IPR029055
Nucleophile aminohydrolases, N-terminal
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PFAM |
PF00227
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P25789
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PhosphoSite |
PhosphoSite-P25789
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5685
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UniGene |
Hs.718340
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RefSeq |
NP_001096138
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HUGO |
HGNC:9533
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OMIM |
176846
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CCDS |
CCDS45319
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HPRD |
10168
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IMGT |
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EMBL |
AC027228
BC005361
BC022445
BC022817
BC047667
BC093069
BT009784
CH471136
D00763
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GenPept |
AAH05361
AAH22445
AAH22817
AAH47667
AAH93069
AAP88786
BAA00660
EAW99163
EAW99164
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