InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HARS

Summary

InnateDB Protein

IDBP-378670.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HARS

Protein Name

histidyl-tRNA synthetase

Synonyms

HRS; USH3B;

Species

Homo sapiens

Ensembl Protein

ENSP00000387893

InnateDB Gene

IDBG-49355 (HARS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	32 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004812	aminoacyl-tRNA ligase activity
GO:0004821	histidine-tRNA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0006412	translation
GO:0006418	tRNA aminoacylation for protein translation
GO:0006427	histidyl-tRNA aminoacylation
GO:0010467	gene expression

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000738 WHEP-TRS
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved domain
IPR004154 Anticodon-binding
IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit
IPR009068 S15/NS1, RNA-binding

PFAM

PF00458
PF00587
PF03129

PRINTS

PIRSF

PIRSF001549

SMART

SM00991

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt