InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LY6D

Summary

InnateDB Protein

IDBP-37868.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LY6D

Protein Name

lymphocyte antigen 6 complex, locus D

Synonyms

E48; Ly-6D;

Species

Homo sapiens

Ensembl Protein

ENSP00000301263

InnateDB Gene

IDBG-37866 (LY6D)

Protein Structure

UniProt Annotation

Function

May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Expressed exclusively at the outer cell surface of transitional epithelia and the keratinocyte of stratified squamous epithelia.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0007155	cell adhesion
GO:0030098	lymphocyte differentiation
GO:0035634	response to stilbenoid

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0031225	anchored component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001526 CD59 antigen
IPR016054 Ly-6 antigen / uPA receptor -like

PFAM

PF00021

PRINTS

PIRSF

SMART

SM00134

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14210

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

8581

UniGene

Hs.415762

RefSeq

NP_003686

HUGO

HGNC:13348

OMIM

606204

CCDS

CCDS6390

HPRD

09370

IMGT

EMBL

AK312164 BC022806 BC031330 CH471162 U66837 X82693 Y12642

GenPept

AAB07524 AAH22806 AAH31330 BAG35098 CAA58014 CAA73189 EAW82297 EAW82298