InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF146

Summary

InnateDB Protein

IDBP-378700.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF146

Protein Name

zinc finger protein 146

Synonyms

OZF;

Species

Homo sapiens

Ensembl Protein

ENSP00000400391

InnateDB Gene

IDBG-46712 (ZNF146)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000269PubMed:8665923}.

Disease Associations

Tissue Specificity

Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers. {ECO:0000269PubMed:8107129, ECO:0000269PubMed:8665923}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008201	heparin binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding