InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDO1

Summary

InnateDB Protein

IDBP-37878.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDO1

Protein Name

cysteine dioxygenase, type I

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000250535

InnateDB Gene

IDBG-37876 (CDO1)

Protein Structure

UniProt Annotation

Function

Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells. {ECO:0000269PubMed:10427686}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008198	ferrous iron binding
GO:0017172	cysteine dioxygenase activity
GO:0047800	cysteamine dioxygenase activity

Biological Process

GO:0000096	sulfur amino acid metabolic process
GO:0000097	sulfur amino acid biosynthetic process
GO:0000098	sulfur amino acid catabolic process
GO:0006534	cysteine metabolic process
GO:0006954	inflammatory response
GO:0007595	lactation
GO:0010243	response to organonitrogen compound
GO:0019448	L-cysteine catabolic process
GO:0033762	response to glucagon
GO:0034641	cellular nitrogen compound metabolic process
GO:0042412	taurine biosynthetic process
GO:0043200	response to amino acid
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046439	L-cysteine metabolic process
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process