InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBFB

Summary

InnateDB Protein

IDBP-378824.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBFB

Protein Name

core-binding factor, beta subunit

Synonyms

PEBP2B;

Species

Homo sapiens

Ensembl Protein

ENSP00000415151

InnateDB Gene

IDBG-35939 (CBFB)

Protein Structure

UniProt Annotation

Function

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM- CSF promoters. CBFB enhances DNA binding by RUNX1.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Note=A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0030098	lymphocyte differentiation
GO:0030099	myeloid cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048469	cell maturation
GO:0060216	definitive hemopoiesis