Version 5.4
Homo sapiens Protein: ATG4A
Summary
InnateDB Protein IDBP-378986.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4A
Protein Name ATG4 autophagy related 4 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000416218
InnateDB Gene IDBG-81860 (ATG4A)
Protein Structure
UniProt Annotation
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269PubMed:12473658, ECO:0000269PubMed:15169837, ECO:0000269PubMed:17347651, ECO:0000269PubMed:21177865, ECO:0000269PubMed:21245471, ECO:0000269PubMed:22302004}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. {ECO:0000269PubMed:12446702, ECO:0000269PubMed:15169837}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Protein Structure and Domains
PDB ID
InterPro IPR005078 Peptidase C54
PFAM PF03416
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q8WYN0
TrEMBL
UniProt Splice Variant
Entrez Gene 115201
UniGene Hs.8763
RefSeq
HUGO HGNC:16489
OMIM 300663
CCDS
HPRD 06455
IMGT
EMBL
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca