Homo sapiens Protein: CTTNBP2
Summary
InnateDB Protein IDBP-37899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTTNBP2
Protein Name cortactin binding protein 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000160373
InnateDB Gene IDBG-37897 (CTTNBP2)
Protein Structure
UniProt Annotation
Function Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance. {ECO:0000250}.
Subcellular Localization Cytoplasm, cell cortex {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Remains associated with dendritic spines even after glutamate stimulation. {ECO:0000250}.
Disease Associations
Tissue Specificity Highest expression in brain. Also expressed in kidney, pancreas, lung, heart, liver, skeletal muscle and placenta. {ECO:0000269PubMed:11707066}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007420 brain development
Cellular Component
GO:0005938 cell cortex
GO:0008021 synaptic vesicle
GO:0043197 dendritic spine
Protein Structure and Domains
PDB ID
InterPro IPR002110 Ankyrin repeat
IPR019131 Cortactin-binding protein-2, N-terminal
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF09727
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WZ74
PhosphoSite PhosphoSite-Q8WZ74
TrEMBL Q20BG9
UniProt Splice Variant
Entrez Gene 83992
UniGene Hs.592285
RefSeq NP_219499
HUGO HGNC:15679
OMIM 609772
CCDS CCDS5774
HPRD 09890
IMGT
EMBL AB051545 AC004240 AC007568 AF377960 BC106000 CH236947 CH471070 DQ354388 DQ354389 DQ354390 DQ354391 DQ356257 DQ356259 DQ356260 DQ356261 DQ356262 DQ356264 DQ388128 DQ388129 DQ388130 DQ388131 DQ388132 DQ388133 DQ388134 DQ388136 DQ388137 DQ388138 DQ388139 DQ388140 DQ388141 DQ388142 DQ388143 DQ388144 DQ388145
GenPept AAC04501 AAI06001 AAL32176 ABC79049 ABC79051 ABC79053 ABC79055 ABC87052 ABC87056 ABC87058 ABC87060 ABC87062 ABC87066 ABD72182 ABD72184 ABD72186 ABD72188 ABD72190 ABD72192 ABD72194 ABD72198 ABD72200 ABD72202 ABD72204 ABD72206 ABD72208 ABD72210 ABD72212 ABD72214 ABD72216 BAB21849 EAL24352 EAW83533