InnateDB Protein
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IDBP-379083.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DPF1
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Protein Name
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D4, zinc and double PHD fingers family 1
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Synonyms
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BAF45b; NEUD4; neuro-d4;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000397354
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InnateDB Gene
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IDBG-48290 (DPF1)
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Protein Structure
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Function |
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001965
Zinc finger, PHD-type
IPR011011
Zinc finger, FYVE/PHD-type
IPR019787
Zinc finger, PHD-finger
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PFAM |
PF00628
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PRINTS |
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PIRSF |
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SMART |
SM00249
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TIGRFAMs |
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Modification |
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SwissProt |
Q92782
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PhosphoSite |
PhosphoSite-Q92782
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TrEMBL |
K7EJD5
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UniProt Splice Variant |
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Entrez Gene |
8193
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UniGene |
Hs.631576
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RefSeq |
NP_004638
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HUGO |
HGNC:20225
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OMIM |
601670
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CCDS |
CCDS33008
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HPRD |
03393
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IMGT |
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EMBL |
AC011479
AK094632
BC125153
CH471126
DA076421
U43843
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GenPept |
AAC50685
AAI25154
BAG52900
EAW56763
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