InnateDB Protein
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IDBP-379116.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KIAA0141
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Protein Name
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KIAA0141
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Synonyms
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DELE;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000396225
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InnateDB Gene
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IDBG-50996 (KIAA0141)
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Protein Structure
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Function |
Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation. {ECO:0000269PubMed:20563667}.
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Subcellular Localization |
Mitochondrion {ECO:0000269PubMed:20563667}.
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Disease Associations |
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Tissue Specificity |
Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon. {ECO:0000269PubMed:8590280}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0008625
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extrinsic apoptotic signaling pathway via death domain receptors
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GO:0043281
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regulation of cysteine-type endopeptidase activity involved in apoptotic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR006597
Sel1-like
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PFAM |
PF08238
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PRINTS |
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PIRSF |
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SMART |
SM00671
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TIGRFAMs |
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Modification |
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SwissProt |
Q14154
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PhosphoSite |
PhosphoSite-Q14154
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9812
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UniGene |
Hs.607496
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RefSeq |
NP_055588
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HUGO |
HGNC:28969
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OMIM |
615741
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CCDS |
CCDS4268
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HPRD |
13780
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IMGT |
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EMBL |
BC007855
BC010452
BC011269
BC011926
D50931
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GenPept |
AAH07855
AAH10452
AAH11269
AAH11926
BAA09490
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