InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PSME3

Summary

InnateDB Protein

IDBP-379136.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSME3

Protein Name

proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

Synonyms

HEL-S-283; Ki; PA28-gamma; PA28G; PA28gamma; REG-GAMMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000409487

InnateDB Gene

IDBG-51809 (PSME3)

Protein Structure

UniProt Annotation

Function

Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. {ECO:0000269PubMed:10835274, ECO:0000269PubMed:11185562, ECO:0000269PubMed:11432824, ECO:0000269PubMed:15111123, ECO:0000269PubMed:18309296, ECO:0000269PubMed:9325261}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10657252, ECO:0000269PubMed:12629132}. Cytoplasm {ECO:0000250}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.