Version 5.4
Homo sapiens Protein: CTSO
Summary
InnateDB Protein IDBP-379198.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTSO
Protein Name cathepsin O
Synonyms CTSO1;
Species Homo sapiens
Ensembl Protein ENSP00000414904
InnateDB Gene IDBG-546402 (CTSO)
Protein Structure
UniProt Annotation
Function Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
Subcellular Localization Lysosome.
Disease Associations
Tissue Specificity Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005764 lysosome
Protein Structure and Domains
PDB ID
InterPro IPR000668 Peptidase C1A, papain C-terminal
PFAM PF00112
PRINTS PR00705
PIRSF
SMART SM00645
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43234
PhosphoSite PhosphoSite-P43234
TrEMBL
UniProt Splice Variant
Entrez Gene 1519
UniGene Hs.75262
RefSeq NP_001325
HUGO HGNC:2542
OMIM 600550
CCDS CCDS3794
HPRD 02772
IMGT
EMBL BC049206 X77383
GenPept AAH49206 CAA54562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca