InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT4A1

Summary

InnateDB Protein

IDBP-379313.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT4A1

Protein Name

sulfotransferase family 4A, member 1

Synonyms

BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1; NST; SULTX3;

Species

Homo sapiens

Ensembl Protein

ENSP00000388285

InnateDB Gene

IDBG-10751 (SULT4A1)

Protein Structure

UniProt Annotation

Function

Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS. {ECO:0000269PubMed:17425406}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the cerebral cortex and frontal lobe, slightly less in the cerebellum, occipital and temporal lobes, relatively low in the medulla and putamen, and lowest in the spinal cord. No expression detected in the pancreas (PubMed:10698717). Highly expressed in fetal brain and occipital lobe, slightly less in the whole brain, frontal lobe, hippocampus, and lung, very low expression in cerebellum, medulla oblongata, temporal lobe, testis, kidney and appendix (PubMed:12039030). {ECO:0000269PubMed:10698717, ECO:0000269PubMed:12039030}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008146	sulfotransferase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0008150	biological_process
GO:0008202	steroid metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process