InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLF5

Summary

InnateDB Protein

IDBP-37934.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLF5

Protein Name

Kruppel-like factor 5 (intestinal)

Synonyms

BTEB2; CKLF; IKLF;

Species

Homo sapiens

Ensembl Protein

ENSP00000366915

InnateDB Gene

IDBG-37932 (KLF5)

Protein Structure

UniProt Annotation

Function

Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15735697}.

Disease Associations

Tissue Specificity

Expressed only in testis and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	41 [view]
Protein-DNA	8 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0030033	microvillus assembly
GO:0032534	regulation of microvillus assembly
GO:0035914	skeletal muscle cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060576	intestinal epithelial cell development
GO:0071407	cellular response to organic cyclic compound
GO:1901653	cellular response to peptide