Version 5.4
Homo sapiens Protein: ANKRD13D
Summary
InnateDB Protein IDBP-379375.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANKRD13D
Protein Name ankyrin repeat domain 13 family, member D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000402616
InnateDB Gene IDBG-59954 (ANKRD13D)
Protein Structure
UniProt Annotation
Function Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269PubMed:22298428}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:22298428}. Late endosome {ECO:0000269PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005770 late endosome
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003903 Ubiquitin interacting motif
IPR021832 Ankyrin repeat domain-containing protein 13
PFAM PF02809
PF11904
PRINTS
PIRSF
SMART SM00726
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZTN6
PhosphoSite PhosphoSite-Q6ZTN6
TrEMBL B3KND9
UniProt Splice Variant
Entrez Gene 338692
UniGene
RefSeq
HUGO HGNC:27880
OMIM 615126
CCDS
HPRD 17349
IMGT
EMBL AK027313 AK057681 AK124721 AK126438 AP001885 BC044239 BC110419 BC121024 BC121025 CH471076
GenPept AAH44239 AAI10420 AAI21025 AAI21026 BAC85932 BAC86550 BAG51301 BAG51952 EAW74584 EAW74585 EAW74586

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca