InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP3S1

Summary

InnateDB Protein

IDBP-37947.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP3S1

Protein Name

adaptor-related protein complex 3, sigma 1 subunit

Synonyms

CLAPS3; Sigma3A;

Species

Homo sapiens

Ensembl Protein

ENSP00000325369

InnateDB Gene

IDBG-37945 (AP3S1)

Protein Structure

UniProt Annotation

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Disease Associations

Tissue Specificity

Present in all adult tissues examined. {ECO:0000269PubMed:8697810, ECO:0000269PubMed:9118953, ECO:0000269PubMed:9151686}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0008089	anterograde axon cargo transport
GO:0008286	insulin receptor signaling pathway
GO:0015031	protein transport
GO:0048490	anterograde synaptic vesicle transport

Cellular Component

GO:0005794	Golgi apparatus
GO:0030119	AP-type membrane coat adaptor complex
GO:0030123	AP-3 adaptor complex
GO:0030133	transport vesicle
GO:0030659	cytoplasmic vesicle membrane