InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATXN7L3

Summary

InnateDB Protein

IDBP-379499.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATXN7L3

Protein Name

ataxin 7-like 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000397259

InnateDB Gene

IDBG-53490 (ATXN7L3)

Protein Structure

UniProt Annotation

Function

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. {ECO:0000255HAMAP- Rule:MF_03047, ECO:0000269PubMed:18206972, ECO:0000269PubMed:21746879}.

Subcellular Localization

Nucleus {ECO:0000255HAMAP-Rule:MF_03047}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0016578	histone deubiquitination
GO:0045893	positive regulation of transcription, DNA-templated