InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PITPNM1

Summary

InnateDB Protein

IDBP-379502.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PITPNM1

Protein Name

phosphatidylinositol transfer protein, membrane-associated 1

Synonyms

DRES9; NIR2; PITPNM; Rd9; RDGB; RDGB1; RDGBA; RDGBA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000398787

InnateDB Gene

IDBG-60549 (PITPNM1)

Protein Structure

UniProt Annotation

Function

Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. {ECO:0000250, ECO:0000269PubMed:10022914, ECO:0000269PubMed:11909959, ECO:0000269PubMed:15545272, ECO:0000269PubMed:15723057}.

Subcellular Localization

Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Cleavage furrow. Midbody. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets. Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10022914}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008526	phosphatidylinositol transporter activity
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0007420	brain development
GO:0007602	phototransduction
GO:0015031	protein transport
GO:0015914	phospholipid transport

Cellular Component

GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016020	membrane
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0032580	Golgi cisterna membrane