Homo sapiens Protein: ITIH3
Summary
InnateDB Protein IDBP-379731.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITIH3
Protein Name inter-alpha (globulin) inhibitor H3
Synonyms H3P;
Species Homo sapiens
Ensembl Protein ENSP00000415769
InnateDB Gene IDBG-39731 (ITIH3)
Protein Structure
UniProt Annotation
Function May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR002035 von Willebrand factor, type A
IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
IPR013694 VIT domain
PFAM PF00092
PF06668
PF08487
PF13757
PRINTS
PIRSF
SMART SM00327
SM00609
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q06033
PhosphoSite PhosphoSite-Q06033
TrEMBL
UniProt Splice Variant
Entrez Gene 3699
UniGene Hs.76716
RefSeq NP_002208
HUGO HGNC:6168
OMIM 146650
CCDS CCDS46845
HPRD 00891
IMGT
EMBL AC006254 AK222757 AK223483 BC107604 BC107605 BC107814 X14690 X67055 X99854
GenPept AAI07605 AAI07606 AAI07815 BAD96477 BAD97203 CAA32821 CAA47439 CAC79611