InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TKT

Summary

InnateDB Protein

IDBP-379878.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TKT

Protein Name

transketolase

Synonyms

HEL107; TK; TKT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000405455

InnateDB Gene

IDBG-40133 (TKT)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004802	transketolase activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0048037	cofactor binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0005999	xylulose biosynthetic process
GO:0006098	pentose-phosphate shunt
GO:0006112	energy reserve metabolic process
GO:0008152	metabolic process
GO:0009052	pentose-phosphate shunt, non-oxidative branch
GO:0044281	small molecule metabolic process
GO:0046166	glyceraldehyde-3-phosphate biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001017 Dehydrogenase, E1 component
IPR005474 Transketolase, N-terminal
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676
PF00456
PF02779
PF02780

PRINTS

PIRSF

SMART

SM00861

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P29401