InnateDB Protein
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IDBP-37996.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AQPEP
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Protein Name
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Aminopeptidase Q
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000350541
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InnateDB Gene
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IDBG-37994 (AQPEP)
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Protein Structure
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Function |
Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met- MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C. {ECO:0000269PubMed:17525158}.
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Subcellular Localization |
Membrane; Single-pass type II membrane protein.
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Disease Associations |
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Tissue Specificity |
Specifically expressed in placenta and not in other tissues. Mainly found at the cell surface region of the extravillous trophoblasts. Detected on extravillous trophoblasts in the outer layer of the chorion laeve in the fetal membrane Not detected on either fetal amnionic epithelial cells or maternal decidual cells. Also detected in the migrating extravillous trophoblasts in the maternal decidual tissues (at protein level). {ECO:0000269PubMed:14706636}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR014782
Peptidase M1, membrane alanine aminopeptidase, N-terminal
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PFAM |
PF01433
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PRINTS |
PR00756
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6Q4G3
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PhosphoSite |
PhosphoSite-Q6Q4G3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
206338
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UniGene |
Hs.98288
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RefSeq |
NP_776161
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HUGO |
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OMIM |
610046
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CCDS |
CCDS4124
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HPRD |
07118
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IMGT |
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EMBL |
AC010282
AC034236
AK075131
AK291655
AY560010
BC036440
BC045809
BC068560
BC070028
BC094716
BC109022
BC109023
CH471086
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GenPept |
AAH68560
AAI09023
AAI09024
AAS66719
BAC11422
BAF84344
EAW48946
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