InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCKAP1L

Summary

InnateDB Protein

IDBP-38004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCKAP1L

Protein Name

NCK-associated protein 1-like

Synonyms

HEM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000293373

InnateDB Gene

IDBG-38002 (NCKAP1L)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed only in cells of hematopoietic origin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0005515	protein binding
GO:0030295	protein kinase activator activity
GO:0030675	Rac GTPase activator activity
GO:0032403	protein complex binding

Biological Process

GO:0001782	B cell homeostasis
GO:0002262	myeloid cell homeostasis
GO:0006461	protein complex assembly
GO:0006935	chemotaxis
GO:0030011	maintenance of cell polarity
GO:0030593	neutrophil chemotaxis
GO:0030838	positive regulation of actin filament polymerization
GO:0030866	cortical actin cytoskeleton organization
GO:0030890	positive regulation of B cell proliferation
GO:0032700	negative regulation of interleukin-17 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032855	positive regulation of Rac GTPase activity
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035509	negative regulation of myosin-light-chain-phosphatase activity
GO:0042102	positive regulation of T cell proliferation
GO:0042327	positive regulation of phosphorylation
GO:0042493	response to drug
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043378	positive regulation of CD8-positive, alpha-beta T cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045579	positive regulation of B cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0048821	erythrocyte development
GO:0050853	B cell receptor signaling pathway
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0070358	actin polymerization-dependent cell motility
GO:0090023	positive regulation of neutrophil chemotaxis