InnateDB Protein
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IDBP-380210.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPP6C
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Protein Name
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protein phosphatase 6, catalytic subunit
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Synonyms
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PP6; PP6C;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000392147
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InnateDB Gene
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IDBG-85080 (PPP6C)
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Protein Structure
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Function |
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. {ECO:0000269PubMed:10227379, ECO:0000269PubMed:17079228, ECO:0000269PubMed:17568194, ECO:0000269PubMed:9013334}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:16769727, ECO:0000269PubMed:17568194}.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. {ECO:0000269PubMed:16769727, ECO:0000269PubMed:9013334}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
67
[view]
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Protein-Protein |
65
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004843
Calcineurin-like phosphoesterase domain, apaH type
IPR006186
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
IPR029052
Metallo-dependent phosphatase-like
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PFAM |
PF00149
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PRINTS |
PR00114
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PIRSF |
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SMART |
SM00156
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TIGRFAMs |
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Modification |
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SwissProt |
O00743
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PhosphoSite |
PhosphoSite-O00743
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TrEMBL |
B7Z3E2
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UniProt Splice Variant |
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Entrez Gene |
5537
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UniGene |
Hs.743623
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RefSeq |
NP_001116827
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HUGO |
HGNC:9323
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OMIM |
612725
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CCDS |
CCDS48018
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HPRD |
02141
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IMGT |
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EMBL |
AF035158
AK295190
AK295752
AK299087
AK312332
AK316527
AL445930
BC006990
BT019708
CH471090
X92972
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GenPept |
AAD45400
AAH06990
AAV38514
BAG35253
BAH12005
BAH12178
BAH12945
BAH14898
CAA63549
CAI13677
EAW87611
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