InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KRR1

Summary

InnateDB Protein

IDBP-380334.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KRR1

Protein Name

KRR1, small subunit (SSU) processome component, homolog (yeast)

Synonyms

HRB2; RIP-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000411740

InnateDB Gene

IDBG-48777 (KRR1)

Protein Structure

UniProt Annotation

Function

Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Note=Translocates from cytoplasm to nucleus after exposure to HIV- 1 virus or HIV-1 protein VPR or induction by hydrocortisone and dexamethasone in the absence of HIV-1 protein VPR.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006364

rRNA processing

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0045171	intercellular bridge

Protein Structure and Domains

PDB ID

InterPro

IPR004087 K Homology domain
IPR004088 K Homology domain, type 1

PFAM

PF00013
PF13014

PRINTS

PIRSF

SMART

SM00322

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13601

PhosphoSite

PhosphoSite-Q13601

TrEMBL

UniProt Splice Variant

Entrez Gene

11103

UniGene

Hs.665628

RefSeq

HUGO

HGNC:5176

OMIM

612817

CCDS

HPRD

11027

IMGT

EMBL

AC022507 AC121761 AK313687 BC005225 BC016778 BC026107 BC033887 EF010919 U55766

GenPept

AAB00557 AAH05225 AAH16778 AAH26107 AAH33887 ABJ97679 BAG36436