InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD36

Summary

InnateDB Protein

IDBP-380352.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD36

Protein Name

CD36 molecule (thrombospondin receptor)

Synonyms

BDPLT10; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3;

Species

Homo sapiens

Ensembl Protein

ENSP00000411411

InnateDB Gene

IDBG-24023 (CD36)

Protein Structure

UniProt Annotation

Function

Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. {ECO:0000269PubMed:10890433, ECO:0000269PubMed:12506336}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Platelet glycoprotein IV deficiency (PG4D) [MIM:608404]: A disorder characterized by macrothrombocytopenia without notable hemostatic problems and bleeding tendency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. {ECO:0000269PubMed:11950861, ECO:0000269PubMed:7533783}. Note=The disease is caused by mutations affecting the gene represented in this entry.Coronary heart disease 7 (CHDS7) [MIM:610938]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269PubMed:15282206}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	20 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0008289	lipid binding
GO:0030169	low-density lipoprotein particle binding
GO:0050431	transforming growth factor beta binding
GO:0070053	thrombospondin receptor activity
GO:0071813	lipoprotein particle binding

Biological Process

GO:0001954	positive regulation of cell-matrix adhesion
GO:0002224	toll-like receptor signaling pathway
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002576	platelet degranulation
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006629	lipid metabolic process
GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0007263	nitric oxide mediated signal transduction
GO:0007596	blood coagulation
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0015911	plasma membrane long-chain fatty acid transport
GO:0019915	lipid storage
GO:0019934	cGMP-mediated signaling
GO:0030168	platelet activation
GO:0030301	cholesterol transport
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034381	plasma lipoprotein particle clearance
GO:0034383	low-density lipoprotein particle clearance
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042953	lipoprotein transport
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0044539	long-chain fatty acid import
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030666	endocytic vesicle membrane
GO:0031092	platelet alpha granule membrane
GO:0045335	phagocytic vesicle