Version 5.4
Homo sapiens Protein: SEMA3C
Summary
InnateDB Protein IDBP-380389.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA3C
Protein Name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Synonyms SEMAE; SemE;
Species Homo sapiens
Ensembl Protein ENSP00000411193
InnateDB Gene IDBG-24094 (SEMA3C)
Protein Structure
UniProt Annotation
Function Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0042493 response to drug
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR016201 Plexin-like fold
PFAM PF01403
PF07679
PRINTS
PIRSF
SMART SM00630
SM00409
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99985
PhosphoSite PhosphoSite-Q99985
TrEMBL Q75MX0
UniProt Splice Variant
Entrez Gene 10512
UniGene Hs.690390
RefSeq
HUGO HGNC:10725
OMIM 602645
CCDS CCDS5596
HPRD 04034
IMGT
EMBL AB000220 AC004880 AC004972 AC073850 AC093683 BC030690
GenPept AAH30690 AAS00351 AAS07489 BAA32398

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca