InnateDB Protein
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IDBP-380414.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CRTC3
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Protein Name
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CREB regulated transcription coactivator 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000416573
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InnateDB Gene
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IDBG-30305 (CRTC3)
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Protein Structure
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Function |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269PubMed:14506290, ECO:0000269PubMed:15454081, ECO:0000269PubMed:15466468, ECO:0000269PubMed:16817901, ECO:0000269PubMed:16980408, ECO:0000269PubMed:17210223, ECO:0000269PubMed:17644518}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Appears to be mainly nuclear.
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Disease Associations |
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Tissue Specificity |
Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. {ECO:0000269PubMed:14536081, ECO:0000269PubMed:16980408}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0008140
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cAMP response element binding protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6UUV7
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PhosphoSite |
PhosphoSite-Q6UUV7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64784
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UniGene |
Hs.739395
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RefSeq |
NP_001036039
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HUGO |
HGNC:26148
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OMIM |
608986
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CCDS |
CCDS45348
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HPRD |
13384
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IMGT |
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EMBL |
AC021422
AC103739
AK025521
AK090443
AY360173
BC074730
BC074731
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GenPept |
AAH74730
AAH74731
AAQ98858
BAB15160
BAC03424
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