InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ODZ1

Summary

InnateDB Protein

IDBP-380539.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ODZ1

Protein Name

odz, odd Oz/ten-m homolog 1 (Drosophila)

Synonyms

ODZ1; ODZ3; TEN-M1; TNM; TNM1;

Species

Homo sapiens

Ensembl Protein

ENSP00000403954

InnateDB Gene

IDBG-85393 (ODZ1)

Protein Structure

UniProt Annotation

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). {ECO:0000250}.Teneurin C-terminal-associated peptide: Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade. Acts also as a bioactive neuroprotective peptide on limbic neurons of the brain and regulates stress-induced behavior: attenuates alkalosis-associated necrotic cell death and the effects of corticotropin-releasing factor (CRF) on c-fos/FOS induction and on the reinstatement of cocaine seeking (By similarity). {ECO:0000250}.Ten-1 intracellular domain: Induces gene transcription activation. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.Ten-1 intracellular domain: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.Teneurin C-terminal-associated peptide: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with the dystroglycan complex at the cell membrane in hippocampal cells. Binds hippocampal cell membranes and is incorporated in the cytoplasm by endocytosis in a caveoli-dependent manner. Upon cell internalization is transported arround and in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in fetal brain. {ECO:0000269PubMed:10341219}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006359	regulation of transcription from RNA polymerase III promoter
GO:0006950	response to stress
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007218	neuropeptide signaling pathway
GO:0007399	nervous system development
GO:0008285	negative regulation of cell proliferation
GO:0030838	positive regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0043406	positive regulation of MAP kinase activity
GO:0051491	positive regulation of filopodium assembly
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016363	nuclear matrix
GO:0016607	nuclear speck
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR006530 YD repeat
IPR008969 Carboxypeptidase-like, regulatory domain
IPR009471 Teneurin intracellular, N-terminal
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF05593
PF06484
PF07974

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UKZ4