InnateDB Protein
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IDBP-380633.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GALNT10
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Protein Name
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UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000415210
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InnateDB Gene
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IDBG-54807 (GALNT10)
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Protein Structure
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Function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed at high level in small intestine, and at intermediate levels in stomach, pancreas, ovary, thyroid gland and spleen. Weakly expressed in other tissues. {ECO:0000269PubMed:12417297}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004653
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polypeptide N-acetylgalactosaminyltransferase activity
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001173
Glycosyltransferase 2-like
IPR029044
Nucleotide-diphospho-sugar transferases
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PFAM |
PF00535
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86SR1
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PhosphoSite |
PhosphoSite-Q86SR1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
55568
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UniGene |
Hs.740431
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RefSeq |
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HUGO |
HGNC:19873
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OMIM |
608043
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CCDS |
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HPRD |
12157
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IMGT |
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EMBL |
AB078145
AJ505950
AK023782
AK074132
AK127135
AL096739
BC007224
BC072450
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GenPept |
AAH07224
AAH72450
BAB14676
BAB84958
BAC56890
BAG54441
CAB46378
CAD44532
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