Homo sapiens Protein: SLCO3A1 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-380749.5 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | SLCO3A1 | ||||||
Protein Name | solute carrier organic anion transporter family, member 3A1 | ||||||
Synonyms | |||||||
Species | Homo sapiens | ||||||
Ensembl Protein | ENSP00000387846 | ||||||
InnateDB Gene | IDBG-30911 (SLCO3A1) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491). {ECO:0000269PubMed:10873595, ECO:0000269PubMed:16971491}. | ||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
Disease Associations | |||||||
Tissue Specificity | Ubiquitous. Highly expressed in spleen and leukocytes. Generally the expression of isoform 1 is higher than that of isoform 2. Isoform 2 is particularly abundant in testis and brain. In testis, isoform 1 is detected in spermatogonia at different stages and absent from Sertoli cells, while isoform 2 is present in both (at protein level). Expressed in the choroid plexus epithelium, isoform 1 being localized at the basolateral membrane and isoform 2 at the apical one, as well as in the subapical intracellular vesicular compartments. Differential expression of both isoforms is also observed in other brain region: isoform 1 is very abundant in the gray matter of the frontal cortex, but is not associated with neuronal cell bodies. Not detected in the white matter. In contrast, isoform 2 is associated with neuronal bodies and axons in both the gray and the white matters of the frontal cortex. {ECO:0000269PubMed:16971491}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | |||||||
InterPro |
IPR002350
Kazal domain IPR004156 Organic anion transporter polypeptide OATP IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter |
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PFAM |
PF00050
PF07648 PF03137 PF07690 |
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PRINTS | |||||||
PIRSF | |||||||
SMART |
SM00280
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TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | Q9UIG8 | ||||||
PhosphoSite | PhosphoSite-Q9UIG8 | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 28232 | ||||||
UniGene | Hs.708469 | ||||||
RefSeq | NP_001138516 | ||||||
HUGO | HGNC:10952 | ||||||
OMIM | 612435 | ||||||
CCDS | CCDS45354 | ||||||
HPRD | 07502 | ||||||
IMGT | |||||||
EMBL | AB031050 AC104020 AC104236 AC113190 AC116903 AC135996 AF187816 AF205074 AK057031 AK097797 AK290872 BC000585 FJ515841 | ||||||
GenPept | AAG42206 AAG43446 AAH00585 ACS13734 BAA89287 BAF83561 BAG51847 BAG53529 | ||||||