InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC6A15

Summary

InnateDB Protein

IDBP-380783.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A15

Protein Name

solute carrier family 6 (neutral amino acid transporter), member 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000390706

InnateDB Gene

IDBG-49844 (SLC6A15)

Protein Structure

UniProt Annotation

Function

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000269PubMed:16226721}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Almost exclusively expressed in the brain. {ECO:0000269PubMed:16226721}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005326	neurotransmitter transporter activity
GO:0005328	neurotransmitter:sodium symporter activity

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0006836	neurotransmitter transport
GO:0006865	amino acid transport
GO:0015804	neutral amino acid transport
GO:0015820	leucine transport
GO:0015824	proline transport
GO:0055085	transmembrane transport