InnateDB Protein
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IDBP-380796.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CEACAM3
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Protein Name
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carcinoembryonic antigen-related cell adhesion molecule 3
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Synonyms
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CD66D; CEA; CGM1; W264; W282;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000411641
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InnateDB Gene
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IDBG-53253 (CEACAM3)
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Protein Structure
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Function |
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. {ECO:0000269PubMed:12864848, ECO:0000269PubMed:14707113}.
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Subcellular Localization |
Membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. {ECO:0000269PubMed:11708798}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P40198
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PhosphoSite |
PhosphoSite-P40198
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TrEMBL |
M0QXR5
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UniProt Splice Variant |
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Entrez Gene |
1084
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UniGene |
Hs.11
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RefSeq |
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HUGO |
HGNC:1815
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OMIM |
609142
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CCDS |
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HPRD |
16450
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IMGT |
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EMBL |
AC022516
AK298694
BC106728
CH471126
D90277
D90278
L00692
L00693
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GenPept |
AAA51969
AAA51970
AAI06729
BAA14321
BAA14322
BAH12850
EAW57062
EAW57063
EAW57064
EAW57065
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