InnateDB Protein
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IDBP-380805.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MED7
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Protein Name
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mediator complex subunit 7
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Synonyms
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ARC34; CRSP33; CRSP9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000401046
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InnateDB Gene
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IDBG-55282 (MED7)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
56
[view]
|
Protein-Protein |
55
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0003713
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transcription coactivator activity
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GO:0005515
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protein binding
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0010467
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gene expression
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Cellular Component |
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PDB ID |
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InterPro |
IPR009244
Mediator complex, subunit Med7
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PFAM |
PF05983
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O43513
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PhosphoSite |
PhosphoSite-O43513
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TrEMBL |
Q6IAZ5
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UniProt Splice Variant |
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Entrez Gene |
9443
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UniGene |
Hs.743448
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RefSeq |
NP_001094286
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HUGO |
HGNC:2378
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OMIM |
605045
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CCDS |
CCDS4334
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HPRD |
05439
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IMGT |
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EMBL |
AC010609
AF031383
AF104251
BC005250
BT007368
CH471062
CR457009
CR541696
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GenPept |
AAC52115
AAD12720
AAP36032
CAG33290
CAG46497
EAW61610
EAW61611
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