Version 5.4
Homo sapiens Protein: HDAC10
Summary
InnateDB Protein IDBP-380909.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HDAC10
Protein Name histone deacetylase 10
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000406150
InnateDB Gene IDBG-12993 (HDAC10)
Protein Structure
UniProt Annotation
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subcellular Localization Cytoplasm. Nucleus. Note=Excluded from the nucleoli.
Disease Associations
Tissue Specificity Ubiquitous. High expression in liver, spleen, pancreas and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0042826 histone deacetylase binding
GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006476 protein deacetylation
GO:0007219 Notch signaling pathway
GO:0016568 chromatin modification
GO:0016575 histone deacetylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
Cellular Component
GO:0000118 histone deacetylase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000286 Histone deacetylase superfamily
IPR023801 Histone deacetylase domain
PFAM PF00850
PRINTS PR01270
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969S8
PhosphoSite PhosphoSite-Q969S8
TrEMBL
UniProt Splice Variant
Entrez Gene 83933
UniGene Hs.26593
RefSeq
HUGO HGNC:18128
OMIM 608544
CCDS
HPRD 09407
IMGT
EMBL AF393962 AF407272 AF407273 AF426160 AL022328 AL512711 AY450395 BC125083 CR456465
GenPept AAI25084 AAK84023 AAK92205 AAK92206 AAL30513 AAS48345 CAC21653 CAG30351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca