InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCB4

Summary

InnateDB Protein

IDBP-380942.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCB4

Protein Name

ATP-binding cassette, sub-family B (MDR/TAP), member 4

Synonyms

ABC21; GBD1; ICP3; MDR2; MDR2/3; MDR3; PFIC-3; PGY3;

Species

Homo sapiens

Ensembl Protein

ENSP00000392983

InnateDB Gene

IDBG-24949 (ABCB4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0016301	kinase activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006629	lipid metabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0042493	response to drug
GO:0042908	xenobiotic transport
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR010488 Zeta toxin domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR019195 ABC transporter, ATPase, putative
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005
PF06414
PF09818

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P21439