Version 5.4
| Homo sapiens Protein: PTGES2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-381278.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | PTGES2 | ||||||||||||||||||
| Protein Name | prostaglandin E synthase 2 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000411378 | ||||||||||||||||||
| InnateDB Gene | IDBG-87283 (PTGES2) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Dual function enzyme which exhibits both isomerase and lyase activities. Its catalytic activity is altered by the presence or absence of the cofactors glutathione (GSH) and heme. The GSH-heme complex-bound enzyme (mPGES-2h) acts as a lyase and catalyzes the degradation of prostaglandin E2 H2 (PGH2) to 12(S)- hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) while the GSH-heme complex-free enzyme (mPGES-2) acts as an isomerase and catalyzes the isomerization of PGH2 into the more stable prostaglandin E2 (PGE2) form (By similarity). {ECO:0000250}. | ||||||||||||||||||
| Subcellular Localization | Golgi apparatus membrane {ECO:0000269PubMed:12835322}; Single-pass membrane protein {ECO:0000269PubMed:12835322}.Prostaglandin E synthase 2 truncated form: Cytoplasm, perinuclear region. Note=Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer. {ECO:0000269PubMed:11866447}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR010987
Glutathione S-transferase, C-terminal-like IPR012336 Thioredoxin-like fold |
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| PFAM |
PF13098
PF13192 PF13462 PF13905 |
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| PRINTS | |||||||||||||||||||
| PIRSF | |||||||||||||||||||
| SMART | |||||||||||||||||||
| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| PhosphoSite | PhosphoSite-Q9H7Z7 | ||||||||||||||||||
| TrEMBL | X6RJ95 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 80142 | ||||||||||||||||||
| UniGene | Hs.495219 | ||||||||||||||||||
| RefSeq | |||||||||||||||||||
| HUGO | HGNC:17822 | ||||||||||||||||||
| OMIM | 608152 | ||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | 07458 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL590708 | ||||||||||||||||||
| GenPept | |||||||||||||||||||