InnateDB Protein
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IDBP-381291.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DEM1
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Protein Name
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defects in morphology 1 homolog (S. cerevisiae)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398437
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InnateDB Gene
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IDBG-96951 (DEM1)
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Protein Structure
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Function |
Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269PubMed:23095756}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0045145
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single-stranded DNA 5'-3' exodeoxyribonuclease activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR019190
Exonuclease V
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PFAM |
PF09810
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q9H790
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TrEMBL |
X6RLK1
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UniProt Splice Variant |
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Entrez Gene |
64789
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UniGene |
Hs.59584
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RefSeq |
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HUGO |
HGNC:26115
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OMIM |
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CCDS |
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HPRD |
07955
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IMGT |
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EMBL |
AL603839
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GenPept |
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