Version 5.4
Homo sapiens Protein: DEM1
Summary
InnateDB Protein IDBP-381299.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DEM1
Protein Name defects in morphology 1 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000392115
InnateDB Gene IDBG-96951 (DEM1)
Protein Structure
UniProt Annotation
Function Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity. {ECO:0000269PubMed:23095756}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23095756}. Cytoplasm, cytosol {ECO:0000269PubMed:23095756}. Note=Localizes to repair foci in response to DNA damage.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity
Biological Process
GO:0000738 DNA catabolic process, exonucleolytic
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR019190 Exonuclease V
PFAM PF09810
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9H790
TrEMBL X6RLK1
UniProt Splice Variant
Entrez Gene 64789
UniGene Hs.59584
RefSeq
HUGO HGNC:26115
OMIM
CCDS
HPRD 07955
IMGT
EMBL AL603839
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca