InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXI1

Summary

InnateDB Protein

IDBP-381399.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXI1

Protein Name

forkhead box I1

Synonyms

FKH10; FKHL10; FREAC-6; FREAC6; HFH-3; HFH3;

Species

Homo sapiens

Ensembl Protein

ENSP00000415483

InnateDB Gene

IDBG-57199 (FOXI1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009790	embryo development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter