InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: URM1

Summary

InnateDB Protein

IDBP-381530.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

URM1

Protein Name

ubiquitin related modifier 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000412922

InnateDB Gene

IDBG-87984 (URM1)

Protein Structure

UniProt Annotation

Function

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {ECO:0000255HAMAP- Rule:MF_03048, ECO:0000269PubMed:19017811, ECO:0000269PubMed:21209336}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016783	sulfurtransferase activity

Biological Process

GO:0002098	tRNA wobble uridine modification
GO:0032447	protein urmylation
GO:0034227	tRNA thio-modification

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR015221 Ubiquitin-related modifier 1
IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp

PFAM

PF09138

PRINTS

PIRSF

PIRSF037379

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AK001880 AK300877 AL359091 BC003581 CH471090

GenPept

AAH03581 BAG50985 BAG62520 CAI13492 CAI13493 EAW87782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca