InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NKX2-5

Summary

InnateDB Protein

IDBP-381623.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NKX2-5

Protein Name

NK2 homeobox 5

Synonyms

CHNG5; CSX; CSX1; HLHS2; NKX2.5; NKX2E; NKX4-1; VSD3;

Species

Homo sapiens

Ensembl Protein

ENSP00000395378

InnateDB Gene

IDBG-58041 (NKX2-5)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0010736	serum response element binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001947	heart looping
GO:0003007	heart morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0003161	cardiac conduction system development
GO:0003221	right ventricular cardiac muscle tissue morphogenesis
GO:0003285	septum secundum development
GO:0007512	adult heart development
GO:0008284	positive regulation of cell proliferation
GO:0010667	negative regulation of cardiac muscle cell apoptotic process
GO:0010735	positive regulation of transcription via serum response element binding
GO:0010765	positive regulation of sodium ion transport
GO:0010832	negative regulation of myotube differentiation
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030878	thyroid gland development
GO:0035050	embryonic heart tube development
GO:0043066	negative regulation of apoptotic process
GO:0045666	positive regulation of neuron differentiation
GO:0045823	positive regulation of heart contraction
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development
GO:0051891	positive regulation of cardioblast differentiation
GO:0055007	cardiac muscle cell differentiation
GO:0055008	cardiac muscle tissue morphogenesis
GO:0055014	atrial cardiac muscle cell development
GO:0055015	ventricular cardiac muscle cell development
GO:0055117	regulation of cardiac muscle contraction
GO:0060037	pharyngeal system development
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060412	ventricular septum morphogenesis
GO:0060413	atrial septum morphogenesis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901387	positive regulation of voltage-gated calcium channel activity