InnateDB Protein
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IDBP-38165.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CCRN4L
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Protein Name
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CCR4 carbon catabolite repression 4-like (S. cerevisiae)
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Synonyms
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Ccr4c; CCR4L; NOC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000280614
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InnateDB Gene
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IDBG-38163 (CCRN4L)
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Protein Structure
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Function |
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase- independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Adipose tissue. Expression is higher in subcutaneous adipose tissue as compared to visceral adipose tissue. {ECO:0000269PubMed:22331129}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR005135
Endonuclease/exonuclease/phosphatase
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PFAM |
PF03372
PF14529
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UK39
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PhosphoSite |
PhosphoSite-Q9UK39
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
25819
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UniGene |
Hs.656047
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RefSeq |
NP_036250
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HUGO |
HGNC:14254
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OMIM |
608468
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CCDS |
CCDS3743
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HPRD |
16337
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IMGT |
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EMBL |
AF183961
AF199492
AF199493
AF199494
BC113494
BC113500
CH471056
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GenPept |
AAD56548
AAG01387
AAG01388
AAG01389
AAI13495
AAI13501
EAX05129
EAX05131
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