Homo sapiens Protein: SLC2A1 | |||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||
InnateDB Protein | IDBP-381854.4 | ||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
Gene Symbol | SLC2A1 | ||||||||||||||||||||||||||||||||
Protein Name | solute carrier family 2 (facilitated glucose transporter), member 1 | ||||||||||||||||||||||||||||||||
Synonyms | DYT17; DYT18; DYT9; EIG12; GLUT; GLUT-1; GLUT1; GLUT1DS; HTLVR; PED; | ||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000416293 | ||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-97330 (SLC2A1) | ||||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||||||
Function | Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. {ECO:0000269PubMed:18245775, ECO:0000269PubMed:19449892}. | ||||||||||||||||||||||||||||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. Melanosome. Note=Localizes primarily at the cell surface. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. | ||||||||||||||||||||||||||||||||
Disease Associations | GLUT1 deficiency syndrome 1 (GLUT1DS1) [MIM:606777]: A neurologic disorder showing wide phenotypic variability. The most severe 'classic' phenotype comprises infantile-onset epileptic encephalopathy associated with delayed development, acquired microcephaly, motor incoordination, and spasticity. Onset of seizures, usually characterized by apneic episodes, staring spells, and episodic eye movements, occurs within the first 4 months of life. Other paroxysmal findings include intermittent ataxia, confusion, lethargy, sleep disturbance, and headache. Varying degrees of cognitive impairment can occur, ranging from learning disabilities to severe mental retardation. {ECO:0000269PubMed:10227690, ECO:0000269PubMed:10980529, ECO:0000269PubMed:11136715, ECO:0000269PubMed:11603379, ECO:0000269PubMed:12325075, ECO:0000269PubMed:15622525, ECO:0000269PubMed:19901175, ECO:0000269PubMed:20129935, ECO:0000269PubMed:20221955, ECO:0000269PubMed:20574033}. Note=The disease is caused by mutations affecting the gene represented in this entry.GLUT1 deficiency syndrome 2 (GLUT1DS2) [MIM:612126]: A clinically variable disorder characterized primarily by onset in childhood of paroxysmal exercise-induced dyskinesia. The dyskinesia involves transient abnormal involuntary movements, such as dystonia and choreoathetosis, induced by exercise or exertion, and affecting the exercised limbs. Some patients may also have epilepsy, most commonly childhood absence epilepsy. Mild mental retardation may also occur. In some patients involuntary exertion- induced dystonic, choreoathetotic, and ballistic movements may be associated with macrocytic hemolytic anemia. {ECO:0000269PubMed:14605501, ECO:0000269PubMed:18451999, ECO:0000269PubMed:19630075, ECO:0000269PubMed:19798636, ECO:0000269PubMed:20129935, ECO:0000269PubMed:20574033, ECO:0000269PubMed:20621801, ECO:0000269PubMed:20830593, ECO:0000269PubMed:21204808}. Note=The disease is caused by mutations affecting the gene represented in this entry.Epilepsy, idiopathic generalized 12 (EIG12) [MIM:614847]: A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Seizure types include juvenile myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. In some EIG12 patients seizures may remit with age. {ECO:0000269PubMed:19798636, ECO:0000269PubMed:22282645}. Note=The disease is caused by mutations affecting the gene represented in this entry.Dystonia 9 (DYT9) [MIM:601042]: An autosomal dominant neurologic disorder characterized by childhood onset of paroxysmal choreoathetosis and progressive spastic paraplegia. Most patients show some degree of cognitive impairment. Other variable features may include seizures, migraine headaches, and ataxia. {ECO:0000269PubMed:21832227}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||||||||||||
Tissue Specificity | Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues. {ECO:0000269PubMed:23219802}. | ||||||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||||||
InterPro |
IPR002439
Glucose transporter, type 1 (GLUT1) IPR003663 Sugar/inositol transporter IPR005828 General substrate transporter IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter IPR020846 Major facilitator superfamily domain |
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PFAM |
PF00083
PF07690 |
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PRINTS |
PR01190
PR00171 |
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PIRSF | |||||||||||||||||||||||||||||||||
SMART | |||||||||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||
SwissProt | P11166 | ||||||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P11166 | ||||||||||||||||||||||||||||||||
TrEMBL | Q59GX2 | ||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||
Entrez Gene | 6513 | ||||||||||||||||||||||||||||||||
UniGene | Hs.473721 | ||||||||||||||||||||||||||||||||
RefSeq | NP_006507 | ||||||||||||||||||||||||||||||||
HUGO | HGNC:11005 | ||||||||||||||||||||||||||||||||
OMIM | 138140 | ||||||||||||||||||||||||||||||||
CCDS | CCDS477 | ||||||||||||||||||||||||||||||||
HPRD | 00683 | ||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||
EMBL | AB208987 AF070544 AK122999 AK292791 AK312403 AY034633 BC118590 CH471059 K03195 M20653 | ||||||||||||||||||||||||||||||||
GenPept | AAA52571 AAB61084 AAC28635 AAI18591 AAK56795 BAD92224 BAF85480 BAG35317 BAG53842 EAX07124 | ||||||||||||||||||||||||||||||||