InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALCR

Summary

InnateDB Protein

IDBP-381972.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALCR

Protein Name

calcitonin receptor

Synonyms

CRT; CT-R; CTR; CTR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000391369

InnateDB Gene

IDBG-27060 (CALCR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004948	calcitonin receptor activity
GO:0005515	protein binding
GO:0008565	protein transporter activity
GO:0032841	calcitonin binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0015031	protein transport
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031623	receptor internalization
GO:0045762	positive regulation of adenylate cyclase activity
GO:0051384	response to glucocorticoid
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001688 GPCR, family 2, calcitonin receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003287 GPCR, family 2, calcitonin receptor family
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR00361
PR01350

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt