InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UCN

Summary

InnateDB Protein

IDBP-38200.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UCN

Protein Name

urocortin

Synonyms

UI; UROC;

Species

Homo sapiens

Ensembl Protein

ENSP00000296099

InnateDB Gene

IDBG-38198 (UCN)

Protein Structure

UniProt Annotation

Function

Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0005515	protein binding
GO:0046811	histone deacetylase inhibitor activity
GO:0051430	corticotropin-releasing hormone receptor 1 binding
GO:0051431	corticotropin-releasing hormone receptor 2 binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007565	female pregnancy
GO:0007611	learning or memory
GO:0007631	feeding behavior
GO:0008306	associative learning
GO:0009060	aerobic respiration
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0030157	pancreatic juice secretion
GO:0030307	positive regulation of cell growth
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031064	negative regulation of histone deacetylation
GO:0031175	neuron projection development
GO:0032099	negative regulation of appetite
GO:0032355	response to estradiol
GO:0032755	positive regulation of interleukin-6 production
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034199	activation of protein kinase A activity
GO:0035176	social behavior
GO:0035483	gastric emptying
GO:0042756	drinking behavior
GO:0043066	negative regulation of apoptotic process
GO:0043117	positive regulation of vascular permeability
GO:0045727	positive regulation of translation
GO:0045740	positive regulation of DNA replication
GO:0045776	negative regulation of blood pressure
GO:0045792	negative regulation of cell size
GO:0045909	positive regulation of vasodilation
GO:0046888	negative regulation of hormone secretion
GO:0048265	response to pain
GO:0051384	response to glucocorticoid
GO:0051461	positive regulation of corticotropin secretion
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0060452	positive regulation of cardiac muscle contraction
GO:0060455	negative regulation of gastric acid secretion
GO:0060547	negative regulation of necrotic cell death
GO:0060548	negative regulation of cell death
GO:0090280	positive regulation of calcium ion import
GO:1901215	negative regulation of neuron death
GO:2000252	negative regulation of feeding behavior
GO:2000987	positive regulation of behavioral fear response

Cellular Component

GO:0005576	extracellular region
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043196	varicosity
GO:0043204	perikaryon
GO:0043679	axon terminus