InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEPT4

Summary

InnateDB Protein

IDBP-382326.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPT4

Protein Name

septin 4

Synonyms

ARTS; BRADEION; CE5B3; H5; hCDCREL-2; MART; PNUTL2; SEP4;

Species

Homo sapiens

Ensembl Protein

ENSP00000402348

InnateDB Gene

IDBG-61280 (SEPT4)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. {ECO:0000250, ECO:0000269PubMed:11146656, ECO:0000269PubMed:15029247, ECO:0000269PubMed:15116257, ECO:0000269PubMed:15837787, ECO:0000269PubMed:9889007, ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules. {ECO:0000269PubMed:11146656, ECO:0000269PubMed:15029247, ECO:0000269PubMed:15116257}.Isoform ARTS: Mitochondrion. Nucleus. Note=While predominantly localized in the mitochondria under resting conditions, isoform ARTS translocates into the nucleus after TGF-beta treatment and apoptosis induction.

Disease Associations

Tissue Specificity

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets. {ECO:0000269PubMed:11146656, ECO:0000269PubMed:11167005, ECO:0000269PubMed:11511094, ECO:0000269PubMed:15116257, ECO:0000269PubMed:15915442, ECO:0000269PubMed:9889007}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0006184	GTP catabolic process
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0031398	positive regulation of protein ubiquitination
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000038 Cell division protein GTP binding
IPR004881 Ribosome biogenesis GTPase RsgA, putative
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00735
PF03193

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43236

PhosphoSite