Version 5.4
Homo sapiens Protein: PHLDB2
Summary
InnateDB Protein IDBP-382347.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHLDB2
Protein Name pleckstrin homology-like domain, family B, member 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000405405
InnateDB Gene IDBG-49473 (PHLDB2)
Protein Structure
UniProt Annotation
Function Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12376540}. Membrane {ECO:0000269PubMed:12376540}; Peripheral membrane protein {ECO:0000269PubMed:12376540}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86SQ0
PhosphoSite PhosphoSite-Q86SQ0
TrEMBL Q8NEI7
UniProt Splice Variant
Entrez Gene 90102
UniGene Hs.732215
RefSeq NP_001127910
HUGO HGNC:29573
OMIM 610298
CCDS CCDS46886
HPRD 06611
IMGT
EMBL AB209903 AF506820 AJ496194 AK092996 AK096151 AL137663 BC031000 BC069194 BC142678 BC150210 CH471052 CR749654
GenPept AAH31000 AAH69194 AAI42679 AAI50211 AAM33634 BAC04014 BAC04713 BAD93140 CAD42711 CAH18447 CAH56386 EAW79690

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca