InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASP4

Summary

InnateDB Protein

IDBP-382632.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASP4

Protein Name

caspase 4, apoptosis-related cysteine peptidase

Synonyms

ICE(rel)II; ICEREL-II; ICH-2; Mih1/TX; TX;

Species

Homo sapiens

Ensembl Protein

ENSP00000388566

InnateDB Gene

IDBG-69557 (CASP4)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Involved in ER-stress induced apoptosis. Cleaves caspase-1. {ECO:0000269PubMed:15123740, ECO:0000269Ref.14}.

Subcellular Localization

Endoplasmic reticulum membrane. Mitochondrion.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	39 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0042981	regulation of apoptotic process
GO:0050727	regulation of inflammatory response
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0072557	IPAF inflammasome complex
GO:0072559	NLRP3 inflammasome complex
GO:0097169	AIM2 inflammasome complex

Protein Structure and Domains

PDB ID

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References