InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IGSF11

Summary

InnateDB Protein

IDBP-382692.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGSF11

Protein Name

immunoglobulin superfamily, member 11

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000406092

InnateDB Gene

IDBG-51041 (IGSF11)

Protein Structure

UniProt Annotation

Function

Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth. {ECO:0000269PubMed:15795899, ECO:0000269PubMed:16108831}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle. {ECO:0000269PubMed:16108831}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0040008	regulation of growth

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain

PFAM

PF07679
PF07686

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5DX21