InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYTH2

Summary

InnateDB Protein

IDBP-382762.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYTH2

Protein Name

cytohesin 2

Synonyms

ARNO; CTS18; CTS18.1; PSCD2; PSCD2L; SEC7L; Sec7p-L; Sec7p-like;

Species

Homo sapiens

Ensembl Protein

ENSP00000408236

InnateDB Gene

IDBG-60540 (CYTH2)

Protein Structure

UniProt Annotation

Function

Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane. {ECO:0000269PubMed:17398095}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17398095}; Peripheral membrane protein {ECO:0000269PubMed:17398095}. Cytoplasm {ECO:0000269PubMed:17398095}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through their association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to the plasma membrane.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	26 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006897	endocytosis
GO:0030036	actin cytoskeleton organization
GO:0030155	regulation of cell adhesion
GO:0032012	regulation of ARF protein signal transduction
GO:0043547	positive regulation of GTPase activity